ARHGDIA Antikörper (N-Term)

Produktnummer ABIN6260030

Produktdetails anti-ARHGDIA Antikörper

Target: ARHGDIA (rho GDP Dissociation Inhibitor (GDI) alpha (ARHGDIA))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARHGDIA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: ARHGDIA Antibody detects endogenous levels of total ARHGDIA.

Homologie: Pig,Bovine,Horse,Sheep,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ARHGDIA, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ARHGDIA

Target: ARHGDIA (rho GDP Dissociation Inhibitor (GDI) alpha (ARHGDIA))

Andere Bezeichnung: ARHGDIA (ARHGDIA Produkte)

Synonyme: GDIA1 antikoerper, NPHS8 antikoerper, RHOGDI antikoerper, RHOGDI-1 antikoerper, Bles01 antikoerper, zgc:55554 antikoerper, zgc:77681 antikoerper, wu:fa96g11 antikoerper, ARHGDIA antikoerper, NV15502 antikoerper, 5330430M07Rik antikoerper, Gdi-1 antikoerper, Rho-GDI antikoerper, RhoDGI antikoerper, RhoGDI-1 antikoerper, arhgdia antikoerper, MGC84535 antikoerper, gdia1 antikoerper, rhogdi antikoerper, rhogdi-1 antikoerper, rhogdi1 antikoerper, Rho GDP dissociation inhibitor alpha antikoerper, Rho GDP dissociation inhibitor (GDI) alpha antikoerper, rho GDP-dissociation inhibitor 2 antikoerper, Rho GDP dissociation inhibitor (GDI) alpha L homeolog antikoerper, ARHGDIA antikoerper, Arhgdia antikoerper, arhgdia antikoerper, LOC100120432 antikoerper, arhgdia.L antikoerper

Hintergrund:

Description: Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.

Gene: ARHGDIA

Molekulargewicht: 28kDa

Gen-ID: 396

UniProt: P52565

Pathways: Neurotrophin Signalübertragung