ASCL1 Antikörper (C-Term)

Produktnummer ABIN6260073

Produktdetails anti-ASCL1 Antikörper

Target: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ASCL1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: ASCL1 Antibody detects endogenous levels of total ASCL1.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ASCL1, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ASCL1

Target: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Andere Bezeichnung: ASCL1 (ASCL1 Produkte)

Synonyme: ASH1 antikoerper, HASH1 antikoerper, MASH1 antikoerper, bHLHa46 antikoerper, AI225900 antikoerper, Mash1 antikoerper, ASCL1 antikoerper, Zash-1a antikoerper, ash antikoerper, asha antikoerper, id:ibd5085 antikoerper, im:7138587 antikoerper, si:dkey-264k15.2 antikoerper, zash1a antikoerper, zasha antikoerper, Xash1 antikoerper, ascl1-A antikoerper, Zash-1b antikoerper, ashb antikoerper, zashb antikoerper, achaete-scute family bHLH transcription factor 1 antikoerper, achaete-scute family bHLH transcription factor 1a antikoerper, achaete-scute family bHLH transcription factor 1 L homeolog antikoerper, achaete-scute complex homolog 1 antikoerper, achaete-scute family bHLH transcription factor 1b antikoerper, ASCL1 antikoerper, Ascl1 antikoerper, ascl1a antikoerper, ascl1.L antikoerper, LOC100220505 antikoerper, ascl1b antikoerper

Hintergrund:

Description: Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation.

Gene: ASCL1

Molekulargewicht: 25 kDa

Gen-ID: 429

UniProt: P50553

Pathways: Dopaminergic Neurogenesis