BIRC2 Antikörper (C-Term)

Produktnummer ABIN6260268

Produktdetails anti-BIRC2 Antikörper

Target: BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BIRC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: BIRC2 Antibody detects endogenous levels of total BIRC2.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human BIRC2, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:400, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu BIRC2

Target: BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))

Andere Bezeichnung: BIRC2 (BIRC2 Produkte)

Synonyme: API1 antikoerper, HIAP2 antikoerper, Hiap-2 antikoerper, MIHB antikoerper, RNF48 antikoerper, c-IAP1 antikoerper, cIAP1 antikoerper, Api2 antikoerper, rIAP1 antikoerper, IAP1 antikoerper, ITA antikoerper, AW146227 antikoerper, Api1 antikoerper, Birc3 antikoerper, HIAP1 antikoerper, IAP2 antikoerper, MIAP1 antikoerper, MIAP2 antikoerper, MIHC antikoerper, cIAP2 antikoerper, mcIAP1 antikoerper, ciap-1 antikoerper, birc3 antikoerper, api1 antikoerper, birc2 antikoerper, c-iap1 antikoerper, ciap1 antikoerper, hiap-2 antikoerper, hiap2 antikoerper, mihb antikoerper, rnf48 antikoerper, baculoviral IAP repeat containing 2 antikoerper, baculoviral IAP repeat-containing 2 antikoerper, baculoviral IAP repeat containing 2 L homeolog antikoerper, BIRC2 antikoerper, Birc2 antikoerper, birc2 antikoerper, birc2.L antikoerper

Hintergrund:

Description: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

Gene: BIRC2

Molekulargewicht: 70kDa

Gen-ID: 329

UniProt: Q13490

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades