BNIP3L/NIX Antikörper (Internal Region)

Produktnummer ABIN6260297

Produktdetails anti-BNIP3L/NIX Antikörper

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BNIP3L/NIX Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: BNIP3L Antibody detects endogenous levels of total BNIP3L.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human BNIP3L, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu BNIP3L/NIX

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Andere Bezeichnung: BNIP3L (BNIP3L Produkte)

Synonyme: BNIP3a antikoerper, NIX antikoerper, NIP3 antikoerper, Nix antikoerper, Nip3 antikoerper, C86132 antikoerper, D14Ertd719e antikoerper, Nip3L antikoerper, bnip3l antikoerper, nip3 antikoerper, zgc:110478 antikoerper, bnip3l2 antikoerper, wu:fb52b03 antikoerper, wu:fc02h04 antikoerper, BCL2 interacting protein 3 like antikoerper, BCL2 interacting protein 3 antikoerper, BCL2/adenovirus E1B interacting protein 3 antikoerper, BCL2/adenovirus E1B interacting protein 3-like antikoerper, BCL2/adenovirus E1B interacting protein 3-like b antikoerper, BCL2/adenovirus E1B interacting protein 3-like a antikoerper, BNIP3L antikoerper, BNIP3 antikoerper, Bnip3l antikoerper, Bnip3 antikoerper, bnip3lb antikoerper, bnip3la antikoerper

Hintergrund:

Description: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.

Gene: BNIP3L

Molekulargewicht: 35 kDa

Gen-ID: 665

UniProt: O60238

Pathways: Autophagie