Casein Kinase 1 gamma 2 Antikörper (C-Term)
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- Target Alle Casein Kinase 1 gamma 2 (CSNK1G2) Antikörper anzeigen
- Casein Kinase 1 gamma 2 (CSNK1G2) (Casein Kinase 1, gamma 2 (CSNK1G2))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Casein Kinase 1 gamma 2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- Casein Kinase Igamma2 Antibody detects endogenous levels of total Casein Kinase Igamma2.
- Homologie
- Pig,Bovine,Sheep,Dog,Chicken,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human Casein Kinase Igamma2, corresponding to a region within C-terminal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product CSNK1G2 Primärantikörper
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- Applikationshinweise
- WB 1:1000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- Casein Kinase 1 gamma 2 (CSNK1G2) (Casein Kinase 1, gamma 2 (CSNK1G2))
- Andere Bezeichnung
- CSNK1G2 (CSNK1G2 Produkte)
- Synonyme
- CK1g2 antikoerper, 2810429I12Rik antikoerper, AI463719 antikoerper, CKI antikoerper, ck1-gamma antikoerper, CSNK1G2 antikoerper, ck1g2 antikoerper, csnk1g2 antikoerper, fj97g11 antikoerper, wu:fj97g11 antikoerper, wz8345 antikoerper, zgc:110719 antikoerper, zgc:153415 antikoerper, casein kinase 1 gamma 2 antikoerper, casein kinase 1, gamma 2 antikoerper, casein kinase 1 gamma 2 L homeolog antikoerper, casein kinase 1, gamma 2a antikoerper, casein kinase 1, gamma 2b antikoerper, CSNK1G2 antikoerper, Csnk1g2 antikoerper, csnk1g2.L antikoerper, csnk1g2 antikoerper, csnk1g2a antikoerper, csnk1g2b antikoerper
- Hintergrund
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Description: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
Gene: CSNK1G2
- Molekulargewicht
- 47kDa
- Gen-ID
- 1455
- UniProt
- P78368
- Pathways
- Hedgehog Signalweg
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