CTNNA1 Antikörper (C-Term)

Produktnummer ABIN6260492

Produktdetails anti-CTNNA1 Antikörper

Target: CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CTNNA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Alpha 1 Catenin Antibody detects endogenous levels of total alpha 1 Catenin.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human alpha 1 Catenin, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu CTNNA1

Target: CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))

Andere Bezeichnung: CTNNA1 (CTNNA1 Produkte)

Synonyme: CAP102 antikoerper, 2010010M04Rik antikoerper, AA517462 antikoerper, AI988031 antikoerper, Catna1 antikoerper, CG17947 antikoerper, CT39986 antikoerper, Dalpha-Cat antikoerper, Dalpha-cat antikoerper, DalphaC antikoerper, Dalphacat antikoerper, Dmcatp antikoerper, Dmel\\CG17947 antikoerper, a-Cat antikoerper, a-cat antikoerper, alpha-CAT antikoerper, alpha-cat antikoerper, alpha-catenin antikoerper, alpha-ctn antikoerper, alphaCAT antikoerper, alphaCat antikoerper, alphacat antikoerper, Alpha-Cat antikoerper, dgri_GLEANR_3829 antikoerper, DgriGH19548 antikoerper, GH19548 antikoerper, ctnna antikoerper, cap102 antikoerper, catna1 antikoerper, ctnna1 antikoerper, catenin alpha 1 antikoerper, catenin (cadherin associated protein), alpha 1 antikoerper, alpha Catenin antikoerper, catenin alpha-1 antikoerper, catenin (cadherin-associated protein), alpha 1 antikoerper, catenin alpha 1 S homeolog antikoerper, CTNNA1 antikoerper, Ctnna1 antikoerper, alpha-Cat antikoerper, Dgri\alpha-Cat antikoerper, Tsp_10127 antikoerper, ctnna1 antikoerper, ctnna1.S antikoerper

Hintergrund:

Description: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Gene: CTNNA1

Molekulargewicht: 100 kDa

Gen-ID: 1495

UniProt: P35221

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location