CCDC99 Antikörper (C-Term)

Produktnummer ABIN6260531

Produktdetails anti-CCDC99 Antikörper

Target: CCDC99 (Coiled-Coil Domain Containing 99 (CCDC99))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCDC99 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: CCDC99 Antibody detects endogenous levels of total CCDC99.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CCDC99, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu CCDC99

Target: CCDC99 (Coiled-Coil Domain Containing 99 (CCDC99))

Andere Bezeichnung: SPDL1 (CCDC99 Produkte)

Synonyme: CCDC99 antikoerper, CG15415 antikoerper, Dmel\\CG15415 antikoerper, SPINDLY antikoerper, ccdc99 antikoerper, 1700018I02Rik antikoerper, 2600001J17Rik antikoerper, 2810049B11Rik antikoerper, AA409762 antikoerper, Ccdc99 antikoerper, RGD1306908 antikoerper, ccdc99-a antikoerper, ccdc99-b antikoerper, spdl1-a antikoerper, spdl1-b antikoerper, spdl1 antikoerper, spindle apparatus coiled-coil protein 1 antikoerper, CG15415 gene product from transcript CG15415-RB antikoerper, Tetratricopeptide repeat (TPR)-like superfamily protein antikoerper, spindle apparatus coiled-coil protein 1 L homeolog antikoerper, spindle apparatus coiled-coil protein 1 S homeolog antikoerper, SPDL1 antikoerper, Spindly antikoerper, SPY antikoerper, spdl1 antikoerper, Spdl1 antikoerper, spdl1.L antikoerper, spdl1.S antikoerper

Hintergrund:

Description: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).

Gene: SPDL1

Molekulargewicht: 70kDa

Gen-ID: 54908

UniProt: Q96EA4