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CD3 epsilon Antikörper (C-Term)

Name: CD3 epsilon Antikörper (C-Term)
SKU: ABIN6260619
Price: 698.46 EUR
Availability: InStock

CD3E Reaktivität: Human, Maus, Ratte WB, IHC, IF, ELISA, ICC Wirt: Kaninchen Polyclonal unconjugated

Western blot analysis of extracts of Jurkat, using CD3E antibody. (CD3 epsilon Antikörper (C-Term))

ABIN6276857 at 1/100 staining Human liver cancer tissue by IHC-P. (CD3 epsilon Antikörper (C-Term))

IHC

ABIN6276857 staining HepG2? (CD3 epsilon Antikörper (C-Term))

IF/ICC

Western blot analysis of extracts from rat muscle, using CD3E Antibody. (CD3 epsilon Antikörper (C-Term))

4 Abbildungen

(1 reference)

Produktnummer ABIN6260619

Datenblatt (PDF)

Target Alle CD3 epsilon (CD3E) Antikörper anzeigen

CD3 epsilon (CD3E)
Bindungsspezifität
24

20

16

16

12

12

9

8

6

4

4

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1
C-Term
Reaktivität
216

171

51

41

18

8

8

8

7

4

4

4

4

3

3

3

3

3

3

1

1

1

1

1
Human, Maus, Ratte
Wirt
132

114

45

23

23

10

1

1

1
Kaninchen
Passende Sekundärantikörper
Klonalität
230

114

6
Polyklonal
Konjugat
126

32

30

21

16

8

8

6

6

5

5

4

4

4

4

4

4

4

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
Dieser CD3 epsilon Antikörper ist unkonjugiert
Applikation
253

138

96

82

76

69

31

27

24

22

14

13

13

12

8

6

4

3

3

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)

Spezifität

CD3 epsilon Antibody detects endogenous levels of total CD3 epsilon.

Homologie

Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Aufreinigung

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen

A synthesized peptide derived from human CD3E, corresponding to a region within C-terminal amino acids.

Isotyp

IgG

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CD3E Reaktivität: Human, Maus, Ratte WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

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anti-CD3 epsilon (CD3E) (C-Term) antibody
CD3E Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

anti-CD3 epsilon (CD3E) (AA 25-207) antibody
CD3E Reaktivität: Human WB, IHC, IP Wirt: Kaninchen Polyclonal unconjugated

anti-CD3 epsilon (CD3E) (AA 28-185) antibody
CD3E Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-CD3 epsilon (CD3E) (AA 23-207) antibody
CD3E Reaktivität: Human WB, IHC, IF, ELISA Wirt: Kaninchen Polyclonal unconjugated

anti-CD3 epsilon (CD3E) antibody
CD3E Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Chimeric YTH 12-5 unconjugated Recombinant Antibody

Applikationshinweise

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 mg/mL

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

-20 °C

Informationen zur Lagerung

Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit

12 months
Guo, Xue, Li, Yang, Wang, Ma, Zhang, Wang, Zhao, Chang, Chen: "Protective effects of triptolide on TLR4 mediated autoimmune and inflammatory response induced myocardial fibrosis in diabetic cardiomyopathy." in: Journal of ethnopharmacology, Vol. 193, pp. 333-344, (2017) (PubMed).
Target

CD3 epsilon (CD3E)

Andere Bezeichnung

CD3E (CD3E Produkte)

Synonyme

cd3e antikoerper, CD3E antikoerper, t3e antikoerper, tcre antikoerper, AI504783 antikoerper, CD3 antikoerper, CD3epsilon antikoerper, T3e antikoerper, T3E antikoerper, TCRE antikoerper, CD3e molecule antikoerper, CD3 antigen, epsilon polypeptide antikoerper, cd3e antikoerper, CD3E antikoerper, Cd3e antikoerper

Hintergrund

Description: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell developement. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).
Gene: CD3E

Molekulargewicht

23kDa

Gen-ID

916

UniProt

P07766

Pathways

T-Zell Rezeptor Signalweg, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway