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CHMP4B Antikörper (N-Term)

CHMP4B Reaktivität: Human, Maus, Ratte IHC, WB, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6260812
  • Target Alle CHMP4B Antikörper anzeigen
    CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))
    Bindungsspezifität
    • 15
    • 7
    • 7
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 44
    • 21
    • 13
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 43
    • 1
    Kaninchen
    Klonalität
    • 43
    • 1
    Polyklonal
    Konjugat
    • 13
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CHMP4B Antikörper ist unkonjugiert
    Applikation
    • 19
    • 19
    • 17
    • 13
    • 13
    • 12
    • 5
    • 3
    • 2
    • 2
    Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    CHMP4B Antibody detects endogenous levels of total CHMP4B.
    Homologie
    Pig,Zebrafish,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human CHMP4B, corresponding to a region within N-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product CHMP4B Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))
    Andere Bezeichnung
    CHMP4B (CHMP4B Produkte)
    Synonyme
    C20orf178 antikoerper, CHMP4A antikoerper, CTPP3 antikoerper, CTRCT31 antikoerper, SNF7 antikoerper, SNF7-2 antikoerper, Shax1 antikoerper, VPS32B antikoerper, Vps32-2 antikoerper, dJ553F4.4 antikoerper, 2010012F05Rik antikoerper, C76846 antikoerper, Snf7-2 antikoerper, RGD1309846 antikoerper, RGD1565889 antikoerper, CHMP4b antikoerper, chmp4b antikoerper, chmp4b.S antikoerper, CHMP4c antikoerper, c20orf178 antikoerper, wu:fc96b02 antikoerper, zgc:55566 antikoerper, charged multivesicular body protein 4B antikoerper, charged multivesicular body protein 4Ba antikoerper, charged multivesicular body protein 4B L homeolog antikoerper, charged multivesicular body protein 4Bb antikoerper, CHMP4B antikoerper, Chmp4b antikoerper, chmp4ba antikoerper, chmp4b.L antikoerper, chmp4bb antikoerper
    Hintergrund

    Description: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

    Gene: CHMP4B

    Molekulargewicht
    29-33 kDa
    Gen-ID
    128866
    UniProt
    Q9H444
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