Claspin Antikörper (N-Term)
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- Target Alle Claspin (CLSPN) Antikörper anzeigen
- Claspin (CLSPN)
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Bindungsspezifität
- N-Term
- Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Claspin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Spezifität
- Claspin Antibody detects endogenous levels of total Claspin.
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human Claspin, corresponding to a region within N-terminal amino acids.
- Isotyp
- IgG
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anti-Claspin (CLSPN) (AA 650-750) antibody
CLSPN Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- Claspin (CLSPN)
- Andere Bezeichnung
- CLSPN (CLSPN Produkte)
- Synonyme
- CLSPN antikoerper, xClaspin antikoerper, B130025E01 antikoerper, C85083 antikoerper, E130314M08Rik antikoerper, claspin antikoerper, claspin S homeolog antikoerper, Clspn antikoerper, CLSPN antikoerper, clspn antikoerper, clspn.S antikoerper
- Hintergrund
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Description: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
Gene: CLSPN
- Molekulargewicht
- 150 kDa
- Gen-ID
- 63967
- UniProt
- Q9HAW4
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