COPS8 Antikörper (Internal Region)

Produktnummer ABIN6260973

Produktdetails anti-COPS8 Antikörper

Target: COPS8 (COP9 Signalosome Subunit 8 (COPS8))

Bindungsspezifität: Internal Region

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COPS8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: COPS8 Antibody detects endogenous levels of total COPS8.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human COPS8, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu COPS8

Target: COPS8 (COP9 Signalosome Subunit 8 (COPS8))

Andere Bezeichnung: COPS8 (COPS8 Produkte)

Synonyme: COP9 antikoerper, CSN8 antikoerper, SGN8 antikoerper, csn8 antikoerper, cops8 antikoerper, MGC76051 antikoerper, MGC80215 antikoerper, DDBDRAFT_0167123 antikoerper, DDBDRAFT_0233107 antikoerper, DDB_0167123 antikoerper, DDB_0233107 antikoerper, zgc:56319 antikoerper, zgc:86840 antikoerper, MGC86182 antikoerper, 9430009J09Rik antikoerper, AA408242 antikoerper, Csn8 antikoerper, Sgn8 antikoerper, CONSTITUTIVE PHOTOMORPHOGENIC 9 antikoerper, COP9 SIGNALOSOME SUBUNIT 8 antikoerper, DL3095C antikoerper, EMB143 antikoerper, EMBRYO DEFECTIVE 143 antikoerper, FCAALL.131 antikoerper, FUS7 antikoerper, FUSCA 7 antikoerper, FUSCA PROTEIN FUS7 antikoerper, CG13383 antikoerper, CG33297 antikoerper, CG42522 antikoerper, CH8 antikoerper, Dch8 antikoerper, Dmel\\CG42522 antikoerper, Dmel_CG13383 antikoerper, l(2)SH1829 antikoerper, l(2)SH2 1829 antikoerper, COP9 signalosome subunit 8 antikoerper, COP9 signalosome subunit 8 S homeolog antikoerper, COP9 signalosome complex subunit 8 antikoerper, COP9 signalosome subunit 8 L homeolog antikoerper, COP9 signalosome, subunit CSN8 antikoerper, COPS8 antikoerper, Cops8 antikoerper, cops8 antikoerper, cops8.S antikoerper, CSN8 antikoerper, csn8 antikoerper, cops8.L antikoerper, COP9 antikoerper

Hintergrund:

Description: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene: COPS8

Molekulargewicht: 23 kDa

Gen-ID: 10920

UniProt: Q99627

Pathways: Zellzyklus