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CUBN Antikörper (N-Term)

CUBN Reaktivität: Human WB, IHC, ICC, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6261105
  • Target Alle CUBN Antikörper anzeigen
    CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))
    Bindungsspezifität
    • 15
    • 7
    • 5
    • 1
    • 1
    N-Term
    Reaktivität
    • 36
    • 9
    • 7
    Human
    Wirt
    • 49
    • 1
    Kaninchen
    Klonalität
    • 41
    • 9
    Polyklonal
    Konjugat
    • 12
    • 10
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CUBN Antikörper ist unkonjugiert
    Applikation
    • 21
    • 15
    • 13
    • 13
    • 7
    • 6
    • 4
    • 4
    • 4
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), ELISA, Immunofluorescence (IF)
    Spezifität
    Cubilin Antibody detects endogenous levels of total Cubilin.
    Homologie
    Pig,Bovine,Horse,Sheep,Dog,Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human Cubilin, corresponding to a region within N-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product CUBN Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))
    Andere Bezeichnung
    CUBN (CUBN Produkte)
    Synonyme
    GP280 antikoerper, IFCR antikoerper, MGA1 antikoerper, AA408369 antikoerper, AL022750 antikoerper, D2Wsu88e antikoerper, gp280 antikoerper, cubilin antikoerper, cubilin (intrinsic factor-cobalamin receptor) antikoerper, LOC411053 antikoerper, CUBN antikoerper, cubn antikoerper, Cubn antikoerper
    Hintergrund

    Description: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.

    Gene: CUBN

    Molekulargewicht
    399kDa
    Gen-ID
    8029
    UniProt
    O60494
    Pathways
    Metabolism of Steroid Hormones and Vitamin D, Lipid Metabolism
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