DDX21 Antikörper (Internal Region)
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- Target Alle DDX21 Antikörper anzeigen
- DDX21 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 21 (DDX21))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser DDX21 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Spezifität
- DDX21 Antibody detects endogenous levels of total DDX21.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human DDX21, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product DDX21 Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000, IHC 1:50-1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- DDX21 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 21 (DDX21))
- Andere Bezeichnung
- DDX21 (DDX21 Produkte)
- Synonyme
- MGC130693 antikoerper, DDX21 antikoerper, cb960 antikoerper, wu:fi30c07 antikoerper, wu:fi34d08 antikoerper, GUA antikoerper, GURDB antikoerper, RH-II/GU antikoerper, RH-II/GuA antikoerper, Ddx21a antikoerper, AI255159 antikoerper, AL022742 antikoerper, D10Ertd645e antikoerper, D10Wsu42e antikoerper, DEAD-box helicase 21 L homeolog antikoerper, DExD-box helicase 21 antikoerper, DEAD-box helicase 21 antikoerper, DEAD (Asp-Glu-Ala-Asp) box helicase 21 antikoerper, DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 antikoerper, ddx21.L antikoerper, DDX21 antikoerper, ddx21 antikoerper, Ddx21 antikoerper
- Hintergrund
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Description: RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233).
Gene: DDX21
- Molekulargewicht
- 87 kDa
- Gen-ID
- 9188
- UniProt
- Q9NR30
- Pathways
- SARS-CoV-2 Protein Interaktom
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