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DGCR8 Antikörper (C-Term)

DGCR8 Reaktivität: Human, Maus, Ratte WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6261282
  • Target Alle DGCR8 Antikörper anzeigen
    DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))
    Bindungsspezifität
    • 8
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 41
    • 15
    • 13
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 34
    • 6
    • 1
    Kaninchen
    Klonalität
    • 29
    • 12
    Polyklonal
    Konjugat
    • 29
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DGCR8 Antikörper ist unkonjugiert
    Applikation
    • 30
    • 17
    • 9
    • 8
    • 6
    • 5
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    DGCR8 Antibody detects endogenous levels of total DGCR8.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human DGCR8, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product DGCR8 Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IF/ICC, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))
    Andere Bezeichnung
    DGCR8 (DGCR8 Produkte)
    Synonyme
    MGC78846 antikoerper, DGCR8 antikoerper, gy1 antikoerper, dgcrk6 antikoerper, C22orf12 antikoerper, DGCRK6 antikoerper, Gy1 antikoerper, pasha antikoerper, D16H22S1742E antikoerper, D16H22S788E antikoerper, D16Wis2 antikoerper, N41 antikoerper, Vo59c07 antikoerper, si:ch211-106a19.4 antikoerper, wu:fc23f08 antikoerper, wu:fc38f06 antikoerper, DGCR8 microprocessor complex subunit L homeolog antikoerper, DiGeorge syndrome critical region gene 8 antikoerper, DGCR8 microprocessor complex subunit antikoerper, DGCR8, microprocessor complex subunit antikoerper, microRNA 3618 antikoerper, dgcr8.L antikoerper, DGCR8 antikoerper, dgcr8 antikoerper, Dgcr8 antikoerper, MIR3618 antikoerper
    Hintergrund

    Description: Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity).

    Gene: DGCR8

    Molekulargewicht
    100kDa
    Gen-ID
    54487
    UniProt
    Q8WYQ5
    Pathways
    Regulatorische RNA Pathways
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