Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

DNA2 Antikörper (Internal Region)

DNA2 Reaktivität: Human, Maus ELISA, WB, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6261326
  • Target Alle DNA2 Antikörper anzeigen
    DNA2 (DNA Replication Helicase 2 Homolog (DNA2))
    Bindungsspezifität
    • 5
    • 1
    Internal Region
    Reaktivität
    • 19
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 19
    Kaninchen
    Klonalität
    • 19
    Polyklonal
    Konjugat
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DNA2 Antikörper ist unkonjugiert
    Applikation
    • 9
    • 6
    • 6
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    DNA2L Antibody detects endogenous levels of total DNA2L.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human DNA2L, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product DNA2 Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    DNA2 (DNA Replication Helicase 2 Homolog (DNA2))
    Andere Bezeichnung
    DNA2 (DNA2 Produkte)
    Synonyme
    DNA2L antikoerper, Dna2l antikoerper, E130315B21Rik antikoerper, PEOA6 antikoerper, hDNA2 antikoerper, XDna2 antikoerper, dna2-A antikoerper, DNA replication helicase/nuclease 2 antikoerper, DNA replication helicase/nuclease 2 S homeolog antikoerper, DNA2 antikoerper, Dna2 antikoerper, dna2.S antikoerper
    Hintergrund

    Description: Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.

    Gene: DNA2

    Molekulargewicht
    120 kDa
    Gen-ID
    1763
    UniProt
    P51530
    Pathways
    Telomere Maintenance, DNA Reparatur, DNA Replication, Synthesis of DNA
Sie sind hier:
Kundenservice