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DTNBP1 Antikörper (C-Term)

DTNBP1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6261377
  • Target Alle DTNBP1 Antikörper anzeigen
    DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))
    Bindungsspezifität
    • 15
    • 8
    • 8
    • 7
    • 7
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 58
    • 27
    • 26
    • 15
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 88
    • 2
    Kaninchen
    Klonalität
    • 88
    • 2
    Polyklonal
    Konjugat
    • 26
    • 9
    • 9
    • 8
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DTNBP1 Antikörper ist unkonjugiert
    Applikation
    • 46
    • 42
    • 29
    • 26
    • 26
    • 11
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Spezifität
    DTNBP1 Antibody detects endogenous levels of total DTNBP1.
    Homologie
    Bovine,Horse
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human DTNBP1, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product DTNBP1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))
    Andere Bezeichnung
    DTNBP1 (DTNBP1 Produkte)
    Synonyme
    5430437B18Rik antikoerper, AW048963 antikoerper, Bloc1s8 antikoerper, dysbindin antikoerper, sdy antikoerper, BLOC1S8 antikoerper, DBND antikoerper, HPS7 antikoerper, My031 antikoerper, SDY antikoerper, dtnbp1 antikoerper, zgc:56462 antikoerper, MGC83903 antikoerper, dbnd antikoerper, hps7 antikoerper, my031 antikoerper, MGC85477 antikoerper, DTNBP1 antikoerper, CG6856 antikoerper, Ddysb antikoerper, Dmel\\CG6856 antikoerper, si:ch211-285p6.1 antikoerper, dystrobrevin binding protein 1 antikoerper, Dysbindin antikoerper, dystrobrevin binding protein 1a antikoerper, dystrobrevin binding protein 1 L homeolog antikoerper, dystrobrevin binding protein 1 S homeolog antikoerper, dystrobrevin binding protein 1b antikoerper, Dtnbp1 antikoerper, DTNBP1 antikoerper, dtbp1 antikoerper, dtnbp1a antikoerper, dtnbp1.L antikoerper, dtnbp1.S antikoerper, dtnbp1 antikoerper, Dysb antikoerper, dtnbp1b antikoerper
    Hintergrund

    Description: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.

    Gene: DTNBP1

    Molekulargewicht
    39kDa
    Gen-ID
    84062
    UniProt
    Q96EV8
    Pathways
    Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling
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