EDEM1 Antikörper (C-Term)

Produktnummer ABIN6261429

Produktdetails anti-EDEM1 Antikörper

Target: EDEM1 (ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EDEM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: EDEM1 Antibody detects endogenous levels of total EDEM1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human EDEM1, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu EDEM1

Target: EDEM1 (ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1))

Andere Bezeichnung: EDEM1 (EDEM1 Produkte)

Synonyme: zgc:55816 antikoerper, edem antikoerper, EDEM1 antikoerper, EDEM antikoerper, A130059K23Rik antikoerper, mKIAA0212 antikoerper, RGD1563633 antikoerper, ER degradation enhancer, mannosidase alpha-like 1 antikoerper, ER degradation enhancing alpha-mannosidase like protein 1 antikoerper, ER degradation-enhancing alpha-mannosidase-like protein 1 antikoerper, ER degradation enhancing alpha-mannosidase like protein 1 L homeolog antikoerper, edem1 antikoerper, EDEM1 antikoerper, LOC100637820 antikoerper, edem1.L antikoerper, Edem1 antikoerper

Hintergrund:

Description: Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.

Gene: EDEM1

Molekulargewicht: 74 kDa

Gen-ID: 9695

UniProt: Q92611

Pathways: ER-Nucleus Signaling