Ephrin A1 Antikörper (Internal Region)

Produktnummer ABIN6261448

Produktdetails anti-Ephrin A1 Antikörper

Target: Ephrin A1 (EFNA1)

Bindungsspezifität: Internal Region

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ephrin A1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: EFNA1 Antibody detects endogenous levels of total EFNA1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human EFNA1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu Ephrin A1

Target: Ephrin A1 (EFNA1)

Andere Bezeichnung: EFNA1 (EFNA1 Produkte)

Synonyme: Xefrin-A1 antikoerper, b61 antikoerper, ecklg antikoerper, efl1 antikoerper, efna1 antikoerper, efna1a antikoerper, elfa-a antikoerper, epha1 antikoerper, eplg1 antikoerper, lerk1 antikoerper, tnfaip4 antikoerper, xelf-a' antikoerper, xelfa antikoerper, AI325262 antikoerper, B61 antikoerper, Efl1 antikoerper, Epl1 antikoerper, Eplg1 antikoerper, Lerk1 antikoerper, ECKLG antikoerper, EFL1 antikoerper, EPLG1 antikoerper, LERK-1 antikoerper, LERK1 antikoerper, TNFAIP4 antikoerper, efna1b antikoerper, MGC130661 antikoerper, ephrin-A1 S homeolog antikoerper, ephrin-A1 antikoerper, ephrin A1 antikoerper, ephrin-A1b antikoerper, ephrin-A1 L homeolog antikoerper, efna1.S antikoerper, efna1 antikoerper, EFNA1 antikoerper, efna1b antikoerper, Efna1 antikoerper, efna1.L antikoerper

Hintergrund:

Description: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

Gene: EFNA1

Molekulargewicht: 24kDa

Gen-ID: 1942

UniProt: P20827

Pathways: RTK Signalweg