EIF3A Antikörper (C-Term)
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- Target Alle EIF3A Antikörper anzeigen
- EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser EIF3A Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- EIF3A Antibody detects endogenous levels of total EIF3A.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human EIF3A, corresponding to a region within C-terminal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product EIF3A Primärantikörper
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- Applikationshinweise
- WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))
- Andere Bezeichnung
- EIF3A (EIF3A Produkte)
- Synonyme
- EIF3 antikoerper, EIF3S10 antikoerper, P167 antikoerper, TIF32 antikoerper, eIF3-p170 antikoerper, eIF3-theta antikoerper, p180 antikoerper, p185 antikoerper, EIF6 antikoerper, A830012B05Rik antikoerper, Csma antikoerper, Eif3 antikoerper, Eif3s10 antikoerper, mKIAA0139 antikoerper, ZH12 antikoerper, eif3s10 antikoerper, eIF3 p110 antikoerper, eIF3a antikoerper, eukaryotic translation initiation factor 3 subunit A antikoerper, eukaryotic translation initiation factor 3, subunit A antikoerper, eukaryotic translation initiation factor 3 subunit A S homeolog antikoerper, translation initiation factor eIF3a antikoerper, EIF3A antikoerper, Eif3a antikoerper, eif3a.S antikoerper, tif32 antikoerper
- Hintergrund
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Description: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815).
Gene: EIF3A
- Molekulargewicht
- 167kDa
- Gen-ID
- 8661
- UniProt
- Q14152
- Pathways
- Ribonucleoprotein Complex Subunit Organization
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