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EYA2 Antikörper (Internal Region)

EYA2 Reaktivität: Human, Ratte WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6261629
  • Target Alle EYA2 Antikörper anzeigen
    EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))
    Bindungsspezifität
    • 15
    • 7
    • 6
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 41
    • 18
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Ratte
    Wirt
    • 53
    • 3
    Kaninchen
    Klonalität
    • 54
    • 2
    Polyklonal
    Konjugat
    • 20
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser EYA2 Antikörper ist unkonjugiert
    Applikation
    • 43
    • 25
    • 13
    • 13
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    EYA2 Antibody detects endogenous levels of total EYA2.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human EYA2, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product EYA2 Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))
    Andere Bezeichnung
    EYA2 (EYA2 Produkte)
    Synonyme
    EYA2 antikoerper, zgc:92279 antikoerper, eab1 antikoerper, Eab1 antikoerper, EAB1 antikoerper, EYA transcriptional coactivator and phosphatase 2 antikoerper, EYA2 antikoerper, eya2 antikoerper, Eya2 antikoerper
    Hintergrund

    Description: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2, in this it is functionally redundant with EYA1 (PubMed:12500905).

    Gene: EYA2

    Molekulargewicht
    59 kDa
    Gen-ID
    2139
    UniProt
    O00167
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