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GSDMD Antikörper

GSDMD Reaktivität: Human WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6262106
  • Target Alle GSDMD Antikörper anzeigen
    GSDMD (Gasdermin D (GSDMD))
    Reaktivität
    • 19
    • 2
    • 1
    Human
    Wirt
    • 16
    • 4
    Kaninchen
    Klonalität
    • 16
    • 4
    Polyklonal
    Konjugat
    • 16
    • 2
    • 1
    • 1
    Dieser GSDMD Antikörper ist unkonjugiert
    Applikation
    • 15
    • 7
    • 5
    • 4
    • 4
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    GSDMD Antibody detects endogenous levels of total GSDMD.
    Homologie
    Pig,Bovine,Horse,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human GSDMD.
    Isotyp
    IgG
    Top Product
    Discover our top product GSDMD Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200 IF/ICC 1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    GSDMD (Gasdermin D (GSDMD))
    Andere Bezeichnung
    GSDMD (GSDMD Produkte)
    Synonyme
    GSDMDC1 antikoerper, GSDMD antikoerper, DF5L antikoerper, DFNA5L antikoerper, 1810036L03Rik antikoerper, AW558049 antikoerper, Dfna5l antikoerper, Gsdmdc1 antikoerper, M2-4 antikoerper, gasdermin D antikoerper, GSDMD antikoerper, Gsdmd antikoerper
    Hintergrund

    Description: Gasdermin-D, N-terminal: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:27418190). After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216). Homooligomerizes within the membrane and forms pores of 10 - 15 nanometers (nm) of inner diameter, possibly allowing the release of mature IL1B and triggering pyroptosis (PubMed:27418190, PubMed:27281216). Exhibits bactericidal activity. Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27281216). Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes (By similarity). Strongly binds to bacterial and mitochondrial lipids, including cardiolipin. Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine (PubMed:27281216).

    Gene: GSDMD

    Molekulargewicht
    50-53 kDa
    Gen-ID
    79792
    UniProt
    P57764
    Pathways
    Inflammasome
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