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HUS1 Antikörper (Internal Region)

HUS1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6262423
  • Target Alle HUS1 Antikörper anzeigen
    HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))
    Bindungsspezifität
    • 15
    • 8
    • 7
    • 7
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 62
    • 4
    Kaninchen
    Klonalität
    • 65
    • 1
    Polyklonal
    Konjugat
    • 23
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HUS1 Antikörper ist unkonjugiert
    Applikation
    • 31
    • 26
    • 13
    • 13
    • 9
    • 8
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    HUS1 Antibody detects endogenous levels of total HUS1.
    Homologie
    Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human HUS1, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product HUS1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))
    Andere Bezeichnung
    HUS1 (HUS1 Produkte)
    Synonyme
    hHUS1 antikoerper, mHus1 antikoerper, XHus1 antikoerper, hus1 antikoerper, HUS1 checkpoint clamp component antikoerper, checkpoint clamp complex protein Hus1 antikoerper, HUS1 checkpoint clamp component L homeolog antikoerper, HUS1 antikoerper, Hus1 antikoerper, hus1 antikoerper, hus1.L antikoerper
    Hintergrund

    Description: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.

    Gene: HUS1

    Molekulargewicht
    31kDa
    Gen-ID
    3364
    UniProt
    O60921
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