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IFITM3 Antikörper (N-Term)

IFITM3 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6262457
  • Target Alle IFITM3 Antikörper anzeigen
    IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))
    Bindungsspezifität
    • 8
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 37
    • 5
    • 4
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 28
    • 6
    • 3
    Kaninchen
    Klonalität
    • 33
    • 4
    Polyklonal
    Konjugat
    • 25
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IFITM3 Antikörper ist unkonjugiert
    Applikation
    • 27
    • 18
    • 10
    • 9
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    IFITM3 Antibody detects endogenous levels of total IFITM3.
    Homologie
    Pig,Sheep
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human IFITM3, corresponding to a region within N-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product IFITM3 Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))
    Andere Bezeichnung
    IFITM3 (IFITM3 Produkte)
    Synonyme
    1110004C05Rik antikoerper, Cd225 antikoerper, Cdw217 antikoerper, DSPA2b antikoerper, Fgls antikoerper, IP15 antikoerper, mil-1 antikoerper, 1-8U antikoerper, rat8 antikoerper, Interferon-induced transmembrane protein 3 antikoerper, interferon induced transmembrane protein 3 antikoerper, ifm3 antikoerper, Ifitm3 antikoerper, IFITM3 antikoerper
    Hintergrund

    Description: IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the  pH in phagocytic endosomes thus establishing an antiviral state.

    Gene: IFITM3

    Molekulargewicht
    15 kDa
    Gen-ID
    10410
    UniProt
    Q01628
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