Interleukin enhancer-binding factor 3 (ILF3) (Internal Region) Antikörper

Produktnummer ABIN6262571

Produktdetails

Target: Interleukin enhancer-binding factor 3 (ILF3)

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: ILF3 Antibody detects endogenous levels of total ILF3.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ILF3, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Antigendetails

Target: Interleukin enhancer-binding factor 3 (ILF3)

Andere Bezeichnung: ILF3 (ILF3 Produkte)

Synonyme: CBTF antikoerper, DRBF antikoerper, DRBP76 antikoerper, MMP4 antikoerper, MPHOSPH4 antikoerper, MPP4 antikoerper, NF-AT-90 antikoerper, NF110 antikoerper, NF110b antikoerper, NF90 antikoerper, NF90a antikoerper, NF90b antikoerper, NFAR antikoerper, NFAR-1 antikoerper, NFAR2 antikoerper, TCP110 antikoerper, TCP80 antikoerper, MBII-26 antikoerper, ilf3 antikoerper, wu:fb37d07 antikoerper, wu:fb94b02 antikoerper, zgc:77030 antikoerper, 4F.1 antikoerper, cbtf122 antikoerper, ilf3-A antikoerper, ubp3 antikoerper, ubp4 antikoerper, xilf3 antikoerper, interleukin enhancer binding factor 3 antikoerper, interleukin enhancer binding factor 3b antikoerper, interleukin enhancer binding factor 3 S homeolog antikoerper, ILF3 antikoerper, Ilf3 antikoerper, ilf3b antikoerper, ilf3.S antikoerper

Hintergrund:

Description: RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 Molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552).

Gene: ILF3

Molekulargewicht: 95kDa

Gen-ID: 3609

UniProt: Q12906

Pathways: M Phase