INSIG1 Antikörper (Internal Region)

Produktnummer ABIN6262599

Produktdetails anti-INSIG1 Antikörper

Target: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser INSIG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: INSIG1 Antibody detects endogenous levels of total INSIG1.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human INSIG1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu INSIG1

Target: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Andere Bezeichnung: INSIG1 (INSIG1 Produkte)

Synonyme: cl-6 antikoerper, cl6 antikoerper, CL-6 antikoerper, CL6 antikoerper, fb55a03 antikoerper, fi35b10 antikoerper, wu:fb55a03 antikoerper, wu:fi35b10 antikoerper, zgc:55439 antikoerper, 1810013C12Rik antikoerper, Insig-1 antikoerper, INSIG-1 antikoerper, insulin induced gene 1 antikoerper, insulin induced gene 1 L homeolog antikoerper, INSIG1 antikoerper, insig1 antikoerper, insig1.L antikoerper, Insig1 antikoerper

Hintergrund:

Description: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.

Gene: INSIG1

Molekulargewicht: 28-31, 66-70 kDa

Gen-ID: 3638

UniProt: O15503

Pathways: ER-Nucleus Signaling