ERN1 Antikörper (Internal Region)
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- Target Alle ERN1 Antikörper anzeigen
- ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ERN1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Spezifität
- IRE1 Antibody detects endogenous levels of total IRE1.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human IRE1, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product ERN1 Primärantikörper
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- Applikationshinweise
- WB 1:1000-3000, IF/ICC 1:200-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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GRP78 silencing enhances hyperoxia-induced alveolar epithelial cell apoptosis via CHOP pathway." in: Molecular medicine reports, Vol. 16, Issue 2, pp. 1493-1501, (2018) (PubMed).
: "SWNHs (Single-Wall Carbon Nanohorns) Supervises Endoplasmic Reticulum (ER) Stress in Hepatocellular Carcinoma." in: Journal of nanoscience and nanotechnology, Vol. 18, Issue 10, pp. 6740-6745, (2018) (PubMed).
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GRP78 silencing enhances hyperoxia-induced alveolar epithelial cell apoptosis via CHOP pathway." in: Molecular medicine reports, Vol. 16, Issue 2, pp. 1493-1501, (2018) (PubMed).
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- Target
- ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
- Andere Bezeichnung
- ERN1 (ERN1 Produkte)
- Synonyme
- IRE1 antikoerper, IRE1P antikoerper, IRE1a antikoerper, hIRE1p antikoerper, 9030414B18Rik antikoerper, AI225830 antikoerper, C85377 antikoerper, Ire1a antikoerper, Ire1alpha antikoerper, Ire1p antikoerper, RGD1559716 antikoerper, Ern1 antikoerper, Ire1 antikoerper, Ire1b antikoerper, sb:eu1005 antikoerper, zgc:109932 antikoerper, endoplasmic reticulum to nucleus signaling 1 antikoerper, endoplasmic reticulum to nucleus signaling 2 antikoerper, endoplasmic reticulum (ER) to nucleus signalling 1 antikoerper, serine/threonine-protein kinase/endoribonuclease IRE1 antikoerper, endoplasmic reticulum (ER) to nucleus signalling 2 antikoerper, ERN1 antikoerper, ERN2 antikoerper, Ern1 antikoerper, LOC524719 antikoerper, Ern2 antikoerper, ern1 antikoerper
- Hintergrund
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Description: Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464, PubMed:11175748, PubMed:12637535, PubMed:9637683, PubMed:21317875). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875).
Gene: ERN1
- Molekulargewicht
- 110 kDa
- Gen-ID
- 2081
- UniProt
- O75460
- Pathways
- ER-Nucleus Signaling, Unfolded Protein Response
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