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KIDINS220 Antikörper (Internal Region)

KIDINS220 Reaktivität: Human, Ratte, Maus WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6262800
  • Target Alle KIDINS220 Antikörper anzeigen
    KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))
    Bindungsspezifität
    • 11
    • 9
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 38
    • 12
    • 11
    • 1
    Human, Ratte, Maus
    Wirt
    • 39
    • 10
    Kaninchen
    Klonalität
    • 39
    • 10
    Polyklonal
    Konjugat
    • 22
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser KIDINS220 Antikörper ist unkonjugiert
    Applikation
    • 30
    • 18
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    KIDINS220 Antibody detects endogenous levels of total KIDINS220.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human KIDINS220, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product KIDINS220 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))
    Andere Bezeichnung
    KIDINS220 (KIDINS220 Produkte)
    Synonyme
    ARMS antikoerper, fj35h03 antikoerper, kidins220 antikoerper, zgc:63531 antikoerper, dZ119J18.2 antikoerper, wu:fj35h03 antikoerper, 3110039L19Rik antikoerper, AI194387 antikoerper, AI316525 antikoerper, C330002I19Rik antikoerper, mKIAA1250 antikoerper, kinase D interacting substrate 220 antikoerper, kinase D-interacting substrate 220 antikoerper, kinase D-interacting substrate 220b antikoerper, kinase D-interacting substrate 220kDa antikoerper, KIDINS220 antikoerper, Kidins220 antikoerper, kidins220b antikoerper
    Hintergrund

    Description: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

    Gene: KIDINS220

    Molekulargewicht
    186-197 kDa
    Gen-ID
    57498
    UniProt
    Q9ULH0
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