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KPNA4 Antikörper (C-Term)

KPNA4 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6262864
  • Target Alle KPNA4 Antikörper anzeigen
    KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))
    Bindungsspezifität
    • 15
    • 7
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 41
    • 36
    • 14
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 50
    • 1
    • 1
    Kaninchen
    Klonalität
    • 51
    • 1
    Polyklonal
    Konjugat
    • 22
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser KPNA4 Antikörper ist unkonjugiert
    Applikation
    • 39
    • 19
    • 14
    • 13
    • 10
    • 8
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    KPNA4 Antibody detects endogenous levels of total KPNA4.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human KPNA4, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product KPNA4 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))
    Andere Bezeichnung
    KPNA4 (KPNA4 Produkte)
    Synonyme
    IPOA3 antikoerper, QIP1 antikoerper, SRP3 antikoerper, 6 antikoerper, ATIMPALPHA3 antikoerper, IMPA-3 antikoerper, IMPORTIN ALPHA 3 antikoerper, IMPORTIN ALPHA ISOFORM 3 antikoerper, MODIFIER OF SNC1 antikoerper, T10M13.16 antikoerper, T10M13_16 antikoerper, LOC100224013 antikoerper, 1110058D08Rik antikoerper, importin antikoerper, ipoa3 antikoerper, qip1 antikoerper, srp3 antikoerper, impa3 antikoerper, wu:fa56d07 antikoerper, wu:fa66g10 antikoerper, wu:fe14c04 antikoerper, wu:fi04h11 antikoerper, wu:fi19b05 antikoerper, karyopherin subunit alpha 4 antikoerper, ARM repeat superfamily protein antikoerper, importin alpha 3 antikoerper, karyopherin (importin) alpha 4 antikoerper, karyopherin alpha 4 (importin alpha 3) S homeolog antikoerper, karyopherin alpha 4 (importin alpha 3) antikoerper, KPNA4 antikoerper, MOS6 antikoerper, LOC100533341 antikoerper, Kpna4 antikoerper, kpna4.S antikoerper, kpna4 antikoerper
    Hintergrund

    Description: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

    Gene: KPNA4

    Molekulargewicht
    57kDa
    Gen-ID
    3840
    UniProt
    O00629
    Pathways
    Protein targeting to Nucleus
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