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LRP4 Antikörper (N-Term)

LRP4 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6263007
  • Target Alle LRP4 Antikörper anzeigen
    LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))
    Bindungsspezifität
    • 11
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 24
    • 19
    • 10
    • 2
    Human, Maus, Ratte
    Wirt
    • 19
    • 16
    • 1
    • 1
    Kaninchen
    Klonalität
    • 21
    • 16
    Polyklonal
    Konjugat
    • 14
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LRP4 Antikörper ist unkonjugiert
    Applikation
    • 24
    • 16
    • 14
    • 13
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Spezifität
    LRP4 Antibody detects endogenous levels of total LRP4.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human LRP4, corresponding to a region within N-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product LRP4 Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))
    Andere Bezeichnung
    LRP4 (LRP4 Produkte)
    Synonyme
    CLSS antikoerper, LRP-4 antikoerper, LRP10 antikoerper, MEGF7 antikoerper, SOST2 antikoerper, Megf7 antikoerper, 6430526J12Rik antikoerper, D230026E03 antikoerper, mdig antikoerper, LRP4 antikoerper, lrp10 antikoerper, megf7 antikoerper, LDL receptor related protein 4 antikoerper, low density lipoprotein receptor-related protein 4 antikoerper, LRP4 antikoerper, Lrp4 antikoerper, lrp4 antikoerper
    Hintergrund

    Description: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity).

    Gene: LRP4

    Molekulargewicht
    212kDa
    Gen-ID
    4038
    UniProt
    O75096
    Pathways
    Skeletal Muscle Fiber Development
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