LRP4 Antikörper (N-Term)

Produktnummer ABIN6263007

Produktdetails anti-LRP4 Antikörper

Target: LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRP4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Spezifität: LRP4 Antibody detects endogenous levels of total LRP4.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human LRP4, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu LRP4

Target: LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))

Andere Bezeichnung: LRP4 (LRP4 Produkte)

Synonyme: CLSS antikoerper, LRP-4 antikoerper, LRP10 antikoerper, MEGF7 antikoerper, SOST2 antikoerper, Megf7 antikoerper, 6430526J12Rik antikoerper, D230026E03 antikoerper, mdig antikoerper, LRP4 antikoerper, lrp10 antikoerper, megf7 antikoerper, LDL receptor related protein 4 antikoerper, low density lipoprotein receptor-related protein 4 antikoerper, LRP4 antikoerper, Lrp4 antikoerper, lrp4 antikoerper

Hintergrund:

Description: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity).

Gene: LRP4

Molekulargewicht: 212kDa

Gen-ID: 4038

UniProt: O75096

Pathways: Skeletal Muscle Fiber Development