MAGEA2B Antikörper (C-Term)

Produktnummer ABIN6263054

Produktdetails anti-MAGEA2B Antikörper

Target: MAGEA2B (Melanoma Antigen Family A, 2B (MAGEA2B))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAGEA2B Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Spezifität: MAGEA2 Antibody detects endogenous levels of total MAGEA2.

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human MAGEA2, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu MAGEA2B

Target: MAGEA2B (Melanoma Antigen Family A, 2B (MAGEA2B))

Andere Bezeichnung: MAGEA2, MAGEA2B (MAGEA2B Produkte)

Synonyme: MAGE2 antikoerper, MAGEA2 antikoerper, MAGE family member A2B antikoerper, MAGEA2B antikoerper

Hintergrund:

Description: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.

Gene: MAGEA2, MAGEA2B

Molekulargewicht: 35 kDa

Gen-ID: 266740, 4101

UniProt: P43356