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MAGEF1 Antikörper (Internal Region)

MAGEF1 Reaktivität: Human, Maus WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6263078
  • Target Alle MAGEF1 Antikörper anzeigen
    MAGEF1 (Melanoma Antigen Family F, 1 (MAGEF1))
    Bindungsspezifität
    • 15
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 35
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus
    Wirt
    • 33
    • 2
    Kaninchen
    Klonalität
    • 35
    Polyklonal
    Konjugat
    • 10
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAGEF1 Antikörper ist unkonjugiert
    Applikation
    • 29
    • 13
    • 13
    • 11
    • 7
    • 4
    • 3
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Spezifität
    MAGF1 Antibody detects endogenous levels of total MAGF1.
    Homologie
    Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human MAGF1, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product MAGEF1 Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    MAGEF1 (Melanoma Antigen Family F, 1 (MAGEF1))
    Andere Bezeichnung
    MAGEF1 (MAGEF1 Produkte)
    Synonyme
    6430590I03Rik antikoerper, MAGEF1 antikoerper, MAGE family member F1 antikoerper, melanoma antigen family F, 1 antikoerper, MAGEF1 antikoerper, Magef1 antikoerper
    Hintergrund

    Description: Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair (PubMed:29225034).

    Gene: MAGEF1

    Molekulargewicht
    35 kDa
    Gen-ID
    64110
    UniProt
    Q9HAY2
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