MBD1 Antikörper (C-Term)
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- Target Alle MBD1 Antikörper anzeigen
- MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Ratte, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MBD1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- MBD1 Antibody detects endogenous levels of total MBD1.
- Homologie
- Pig,Horse,Sheep,Rabbit,Dog
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human MBD1, corresponding to a region within C-terminal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product MBD1 Primärantikörper
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anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (AA 415-508) antibody
MBD1 Reaktivität: Human WB, ELISA, IHC (p) Wirt: Maus Monoclonal 2C7 unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (AA 415-508) antibodyMBD1 Reaktivität: Human WB, ELISA, IF Wirt: Maus Monoclonal 4F6 unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (AA 1-605) antibodyMBD1 Reaktivität: Human WB, IF Wirt: Maus Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (AA 106-355) antibodyMBD1 Reaktivität: Human ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (AA 376-405), (C-Term) antibodyMBD1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB2371 unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (C-Term) antibodyMBD1 Reaktivität: Human, Ratte, Hund, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd, Maus, Affe, Fledermaus, Schwein WB, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (N-Term) antibodyMBD1 Reaktivität: Human WB, ELISA, ChIP Wirt: Kaninchen Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (C-Term) antibodyMBD1 Reaktivität: Human, Ratte, Hund, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) (AA 1-605) antibodyMBD1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-Methyl-CpG Binding Domain Protein 1 (MBD1) antibodyMBD1 Reaktivität: Human IHC, StM Wirt: Maus Monoclonal CPTC-MBD1-1 unconjugated
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- Applikationshinweise
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))
- Andere Bezeichnung
- MBD1 (MBD1 Produkte)
- Synonyme
- CXXC3 antikoerper, PCM1 antikoerper, RFT antikoerper, Cxxc3 antikoerper, CCDC11 antikoerper, methyl-CpG binding domain protein 1 antikoerper, MBD1 antikoerper, Mbd1 antikoerper
- Hintergrund
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Description: Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
Gene: MBD1
- Molekulargewicht
- 67 kDa
- Gen-ID
- 4152
- UniProt
- Q9UIS9
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