NDC80 Antikörper (C-Term)

Produktnummer ABIN6263548

Produktdetails anti-NDC80 Antikörper

Target: NDC80 (NDC80 Kinetochore Complex Component Homolog (NDC80))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NDC80 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: NDC80 Antibody detects endogenous levels of total NDC80.

Homologie: Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NDC80, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu NDC80

Target: NDC80 (NDC80 Kinetochore Complex Component Homolog (NDC80))

Andere Bezeichnung: NDC80 (NDC80 Produkte)

Synonyme: CG9938 antikoerper, Dmel\\CG9938 antikoerper, Hec1 antikoerper, NDC80 antikoerper, dNdc80 antikoerper, dmNdc80 antikoerper, hec1 antikoerper, KNTC2 antikoerper, ndc10 antikoerper, tid3 antikoerper, 2610020P18Rik antikoerper, AV139730 antikoerper, HEC antikoerper, HEC1 antikoerper, Kntc2 antikoerper, kntc2l antikoerper, wu:fb52e02 antikoerper, zgc:111801 antikoerper, HsHec1 antikoerper, TID3 antikoerper, hsNDC80 antikoerper, kntc2 antikoerper, NDC80, kinetochore complex component antikoerper, CG9938 gene product from transcript CG9938-RA antikoerper, spindle pole body protein Ndc80 antikoerper, kinetochore protein Ndc80 antikoerper, NDC80 homolog, kinetochore complex component (S. cerevisiae) antikoerper, NDC80 kinetochore complex component antikoerper, NDC80 kinetochore complex component S homeolog antikoerper, NDC80 antikoerper, Ndc80 antikoerper, ndc80 antikoerper, ndc80.S antikoerper

Hintergrund:

Description: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108).

Gene: NDC80

Molekulargewicht: 74kDa

Gen-ID: 10403

UniProt: O14777

Pathways: Maintenance of Protein Location