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Norrie Disease (Pseudoglioma) Antikörper

NDP Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6263552
  • Target Alle Norrie Disease (Pseudoglioma) (NDP) Antikörper anzeigen
    Norrie Disease (Pseudoglioma) (NDP)
    Reaktivität
    • 34
    • 12
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 32
    • 3
    Kaninchen
    Klonalität
    • 34
    • 1
    Polyklonal
    Konjugat
    • 13
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser Norrie Disease (Pseudoglioma) Antikörper ist unkonjugiert
    Applikation
    • 11
    • 8
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Spezifität
    NDP Antibody detects endogenous levels of total NDP
    Kreuzreaktivität
    Human, Maus, Ratte (Rattus)
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human NDP
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:500-1:2000 IHC 1:50-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C.Stable for 12 months from date of receipt
    Haltbarkeit
    12 months
  • Target
    Norrie Disease (Pseudoglioma) (NDP)
    Andere Bezeichnung
    NDP (NDP Produkte)
    Synonyme
    EVR2 antikoerper, FEVR antikoerper, ND antikoerper, evr2 antikoerper, fevr antikoerper, xnorrin antikoerper, Ndph antikoerper, RGD1563968 antikoerper, NDP, norrin cystine knot growth factor antikoerper, Norrie disease (pseudoglioma) L homeolog antikoerper, Norrie disease (pseudoglioma) (human) antikoerper, NDP antikoerper, ndp.L antikoerper, Ndp antikoerper
    Hintergrund

    Description: Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.

    Gene: NDP

    Molekulargewicht
    15kDa
    Gen-ID
    4693
    UniProt
    Q00604
    Pathways
    Sensory Perception of Sound
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