p107 Antikörper (C-Term)
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- Target Alle p107 (RBL1) Antikörper anzeigen
- p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser p107 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Spezifität
- P107 Antibody detects endogenous levels of total p107.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human p107, corresponding to a region within C-terminal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product RBL1 Primärantikörper
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anti-Retinoblastoma-Like 1 (p107) (RBL1) (pSer975) antibody
RBL1 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB7537 unconjugated
anti-Retinoblastoma-Like 1 (p107) (RBL1) (AA 905-1014) antibodyRBL1 Reaktivität: Human WB, ELISA, PLA Wirt: Maus Monoclonal 1A5 unconjugated
anti-Retinoblastoma-Like 1 (p107) (RBL1) (AA 1007-1035), (C-Term) antibodyRBL1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB40387 unconjugated
anti-Retinoblastoma-Like 1 (p107) (RBL1) (AA 1-1014) antibodyRBL1 Reaktivität: Human WB, IF Wirt: Maus Polyclonal unconjugated
anti-Retinoblastoma-Like 1 (p107) (RBL1) (AA 201-500) antibodyRBL1 Reaktivität: Human WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-Retinoblastoma-Like 1 (p107) (RBL1) (pSer975) antibodyRBL1 Reaktivität: Human, Maus, Ratte WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Retinoblastoma-Like 1 (p107) (RBL1) (AA 100-200) antibodyRBL1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-Retinoblastoma-Like 1 (p107) (RBL1) (AA 143-192) antibodyRBL1 Reaktivität: Human, Maus, Rind (Kuh), Pferd, Schwein, Hund, Fledermaus WB Wirt: Kaninchen Polyclonal unconjugated
anti-Retinoblastoma-Like 1 (p107) (RBL1) (AA 935-984) antibodyRBL1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Pferd, Schwein, Hund, Fledermaus, Affe WB Wirt: Kaninchen Polyclonal unconjugated
anti-Retinoblastoma-Like 1 (p107) (RBL1) (N-Term) antibodyRBL1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Pferd, Schwein, Hund, Kaninchen, Meerschweinchen WB Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- WB 1:500-1:2000, IHC 1:50-1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))
- Andere Bezeichnung
- RBL1 (RBL1 Produkte)
- Hintergrund
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Description: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
Gene: RBL1
- Molekulargewicht
- 119 kDa
- Gen-ID
- 5933
- UniProt
- P28749
- Pathways
- Zellzyklus, Mitotic G1-G1/S Phases
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