PIEZO1 Antikörper (Internal Region)
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- Target Alle PIEZO1 Antikörper anzeigen
- PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PIEZO1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- Piezo1 Antibody detects endogenous levels of total Piezo1.
- Homologie
- Pig,Bovine,Horse,Dog,Chicken,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human Piezo1, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product PIEZO1 Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))
- Andere Bezeichnung
- PIEZO1 (PIEZO1 Produkte)
- Synonyme
- DHS antikoerper, FAM38A antikoerper, Mib antikoerper, 9630020g22 antikoerper, Fam38a antikoerper, mKIAA0233 antikoerper, piezo type mechanosensitive ion channel component 1 antikoerper, piezo-type mechanosensitive ion channel component 1 antikoerper, PIEZO1 antikoerper, Piezo1 antikoerper
- Hintergrund
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Description: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity).
Gene: PIEZO1
- Molekulargewicht
- 287 kDa
- Gen-ID
- 9780
- UniProt
- Q92508
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