PITX3 Antikörper
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- Target Alle PITX3 Antikörper anzeigen
- PITX3 (Pituitary Homeobox 3 (PITX3))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PITX3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Spezifität
- PITX3 Antibody detects endogenous levels of total PITX3
- Kreuzreaktivität
- Human, Maus, Ratte (Rattus)
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human PITX3
- Isotyp
- IgG
- Top Product
- Discover our top product PITX3 Primärantikörper
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- Applikationshinweise
- WB 1:1000-3000 IHC 1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C.Stable for 12 months from date of receipt
- Haltbarkeit
- 12 months
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- Target
- PITX3 (Pituitary Homeobox 3 (PITX3))
- Andere Bezeichnung
- PITX3 (PITX3 Produkte)
- Synonyme
- CTPP4 antikoerper, CTRCT11 antikoerper, PTX3 antikoerper, pitx3 antikoerper, Ptx3 antikoerper, ak antikoerper, zgc:109716 antikoerper, pitx3-A antikoerper, xPitx3 antikoerper, paired like homeodomain 3 antikoerper, paired-like homeodomain 3 antikoerper, paired like homeodomain 3 L homeolog antikoerper, paired-like homeodomain transcription factor 3 antikoerper, paired-like homeodomain transcription factor Pitx3 antikoerper, PITX3 antikoerper, Pitx3 antikoerper, pitx3.L antikoerper, pitx3 antikoerper
- Hintergrund
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Description: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).
Gene: PITX3
- Molekulargewicht
- 32 kDa
- Gen-ID
- 5309
- UniProt
- O75364
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