PRKRA Antikörper (Internal Region)
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- Target Alle PRKRA Antikörper anzeigen
- PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PRKRA Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- PRKRA Antibody detects endogenous levels of total PRKRA.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human PRKRA, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product PRKRA Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))
- Andere Bezeichnung
- PRKRA (PRKRA Produkte)
- Synonyme
- PRKRA antikoerper, AV120107 antikoerper, PRK antikoerper, Pact antikoerper, RAX antikoerper, lear antikoerper, DYT16 antikoerper, PACT antikoerper, im:7151758 antikoerper, zgc:162619 antikoerper, dyt16 antikoerper, pact antikoerper, prkra-a antikoerper, prkra-b antikoerper, rax antikoerper, rbpa antikoerper, protein activator of interferon induced protein kinase EIF2AK2 antikoerper, protein kinase, interferon inducible double stranded RNA dependent activator antikoerper, protein kinase, interferon-inducible double stranded RNA dependent activator antikoerper, protein activator of interferon induced protein kinase EIF2AK2 L homeolog antikoerper, PRKRA antikoerper, Prkra antikoerper, prkra antikoerper, prkra.L antikoerper
- Hintergrund
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Description: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).
Gene: PRKRA
- Molekulargewicht
- 34kDa
- Gen-ID
- 8575
- UniProt
- O75569
- Pathways
- Regulatorische RNA Pathways
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