PRMT1 Antikörper (C-Term)

Produktnummer ABIN6264433

Produktdetails anti-PRMT1 Antikörper

Target: PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRMT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: PRMT1 Antibody detects endogenous levels of total PRMT1.

Homologie: Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PRMT1, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PRMT1

Target: PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))

Andere Bezeichnung: PRMT1 (PRMT1 Produkte)

Synonyme: ANM1 antikoerper, HCP1 antikoerper, HRMT1L2 antikoerper, IR1B4 antikoerper, 6720434D09Rik antikoerper, AW214366 antikoerper, Hrmt1l2 antikoerper, Mrmt1 antikoerper, 3E10 antikoerper, anm1 antikoerper, hcp1 antikoerper, hrmt1l2 antikoerper, ir1b4 antikoerper, prmt1 antikoerper, prmt1b antikoerper, xPRMT1b antikoerper, xprmt1 antikoerper, xPRMT1 antikoerper, ARABIDOPSIS THALIANA PROTEIN ARGININE METHYLTRANSFERASE 1A antikoerper, ATPRMT1A antikoerper, F6F22.30 antikoerper, F6F22_30 antikoerper, protein arginine methyltransferase 1A antikoerper, DDBDRAFT_0183976 antikoerper, DDBDRAFT_0235399 antikoerper, DDB_0183976 antikoerper, DDB_0235399 antikoerper, PRMT1 antikoerper, DKFZp459J1326 antikoerper, fb39h07 antikoerper, wu:fb39h07 antikoerper, zf1 antikoerper, zgc:66201 antikoerper, protein arginine methyltransferase 1 antikoerper, protein arginine N-methyltransferase 1 antikoerper, protein arginine methyltransferase 1 L homeolog antikoerper, protein arginine methyltransferase 1 S homeolog antikoerper, protein arginine methyltransferase 1A antikoerper, protein arginine N-methyltransferase-1 antikoerper, protein arginine N-methyltransferase antikoerper, protein arginine methyltransferase antikoerper, PRMT1 antikoerper, Prmt1 antikoerper, prmt1.L antikoerper, prmt1.S antikoerper, PRMT1A antikoerper, prm-1 antikoerper, EDI_007800 antikoerper, Smp_029240.3 antikoerper, prmt1 antikoerper

Hintergrund:

Description: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:16879614). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).

Gene: PRMT1

Molekulargewicht: 42kDa

Gen-ID: 3276

UniProt: Q99873