RASSF1 Antikörper (Internal Region)

Produktnummer ABIN6264654

Produktdetails anti-RASSF1 Antikörper

Target: RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RASSF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: RASSF1 Antibody detects endogenous levels of total RASSF1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RASSF1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu RASSF1

Target: RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))

Andere Bezeichnung: RASSF1 (RASSF1 Produkte)

Synonyme: RASSF1 antikoerper, zgc:92505 antikoerper, wu:fc17f02 antikoerper, zgc:112224 antikoerper, 123F2 antikoerper, NORE2A antikoerper, RASSF1A antikoerper, RDA32 antikoerper, REH3P21 antikoerper, AA536941 antikoerper, AU044980 antikoerper, Rassf1A antikoerper, Rassf1B antikoerper, Rassf1C antikoerper, NPR2-like, GATOR1 complex subunit antikoerper, Ras association (RalGDS/AF-6) domain family 1 antikoerper, Ras association domain family member 1 antikoerper, putative rassf1 antikoerper, Ras association domain family member 1 L homeolog antikoerper, Ras association (RalGDS/AF-6) domain family member 1 antikoerper, NPRL2 antikoerper, rassf1 antikoerper, RASSF1 antikoerper, Smp_157340 antikoerper, rassf1.L antikoerper, Rassf1 antikoerper

Hintergrund:

Description: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

Gene: RASSF1

Molekulargewicht: 39kDa

Gen-ID: 11186

UniProt: Q9NS23