RBBP6 Antikörper (Internal Region)
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- Target Alle RBBP6 Antikörper anzeigen
- RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser RBBP6 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Spezifität
- RBBP6 Antibody detects endogenous levels of total RBBP6.
- Homologie
- Pig,Bovine,Sheep,Rabbit,Dog,Chicken
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human RBBP6, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product RBBP6 Primärantikörper
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- Applikationshinweise
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))
- Andere Bezeichnung
- RBBP6 (RBBP6 Produkte)
- Synonyme
- MY038 antikoerper, P2P-R antikoerper, PACT antikoerper, RBQ-1 antikoerper, SNAMA antikoerper, 4933422O15Rik antikoerper, AI316869 antikoerper, BB233631 antikoerper, C030034J04Rik antikoerper, C77662 antikoerper, rbbp6 antikoerper, MGC75882 antikoerper, RBBP6 antikoerper, im:7158869 antikoerper, rbbp6l antikoerper, RB binding protein 6, ubiquitin ligase antikoerper, retinoblastoma binding protein 6, ubiquitin ligase antikoerper, retinoblastoma binding protein 6 antikoerper, RBBP6 antikoerper, Rbbp6 antikoerper, rbbp6 antikoerper
- Hintergrund
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Description: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53, may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).
Gene: RBBP6
- Molekulargewicht
- 202 kDa
- Gen-ID
- 5930
- UniProt
- Q7Z6E9
- Pathways
- Regulatorische RNA Pathways
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