RNF41 Antikörper (Internal Region)

Produktnummer ABIN6264789

Produktdetails anti-RNF41 Antikörper

Target: RNF41 (Ring Finger Protein 41 (RNF41))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF41 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: RNF41 Antibody detects endogenous levels of total RNF41.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RNF41, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu RNF41

Target: RNF41 (Ring Finger Protein 41 (RNF41))

Andere Bezeichnung: RNF41 (RNF41 Produkte)

Synonyme: FLRF antikoerper, NRDP1 antikoerper, 2210404G21Rik antikoerper, 4930511A05Rik antikoerper, 4933415P08Rik antikoerper, D10Ertd722e antikoerper, Nrdp1 antikoerper, wu:fi13f07 antikoerper, wu:fi25b06 antikoerper, zgc:55389 antikoerper, flrf antikoerper, ring finger protein 41 antikoerper, ring finger protein 41 S homeolog antikoerper, ring finger protein 41, E3 ubiquitin protein ligase antikoerper, RNF41 antikoerper, Rnf41 antikoerper, rnf41 antikoerper, rnf41.S antikoerper

Hintergrund:

Description: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).

Gene: RNF41

Molekulargewicht: 36 kDa

Gen-ID: 10193

UniProt: Q9H4P4

Pathways: SARS-CoV-2 Protein Interaktom