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MST1R Antikörper (C-Term)

MST1R Reaktivität: Human, Maus WB, ELISA, ICC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6264804
  • Target Alle MST1R Antikörper anzeigen
    MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))
    Bindungsspezifität
    • 36
    • 19
    • 14
    • 11
    • 11
    • 11
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 89
    • 55
    • 36
    • 5
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 100
    • 3
    • 2
    Kaninchen
    Klonalität
    • 95
    • 10
    Polyklonal
    Konjugat
    • 35
    • 8
    • 7
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Dieser MST1R Antikörper ist unkonjugiert
    Applikation
    • 73
    • 32
    • 21
    • 19
    • 16
    • 15
    • 15
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Spezifität
    RON Antibody detects endogenous levels of total RON.
    Homologie
    Bovine,Horse,Sheep,Rabbit,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human RON, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product MST1R Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))
    Andere Bezeichnung
    MST1R (MST1R Produkte)
    Synonyme
    CD136 antikoerper, CDw136 antikoerper, PTK8 antikoerper, RON antikoerper, Fv-2 antikoerper, Fv2 antikoerper, Ron antikoerper, STK antikoerper, Cdw136 antikoerper, Ptk8 antikoerper, Stk antikoerper, macrophage stimulating 1 receptor antikoerper, macrophage stimulating 1 receptor (c-met-related tyrosine kinase) antikoerper, MST1R antikoerper, Mst1r antikoerper
    Hintergrund

    Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

    Gene: MST1R

    Molekulargewicht
    152kDa
    Gen-ID
    4486
    UniProt
    Q04912
    Pathways
    RTK Signalweg
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