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PHLPP1 Antikörper (C-Term)

PHLPP1 Reaktivität: Human, Maus, Ratte WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6264947
  • Target Alle PHLPP1 Antikörper anzeigen
    PHLPP1 (PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
    Bindungsspezifität
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 32
    Kaninchen
    Klonalität
    • 32
    Polyklonal
    Konjugat
    • 18
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser PHLPP1 Antikörper ist unkonjugiert
    Applikation
    • 15
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Spezifität
    SCOP Antibody detects endogenous levels of total SCOP.
    Homologie
    Pig,Horse,Rabbit
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human SCOP, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product PHLPP1 Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Dai, Zhang, Cheng, Yang, Chen, Liu, Wang, Yang, Jiang: "RNA-binding Protein Trinucleotide repeat-containing 6A Regulates the Formation of Circular RNA 0006916, with Important Functions in Lung Cancer Cells." in: Carcinogenesis, (2018) (PubMed).

  • Target
    PHLPP1 (PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
    Andere Bezeichnung
    PHLPP1 (PHLPP1 Produkte)
    Synonyme
    PHLPP antikoerper, PLEKHE1 antikoerper, SCOP antikoerper, AI836256 antikoerper, Phlpp antikoerper, Plekhe1 antikoerper, mKIAA0606 antikoerper, Scop antikoerper, PH domain and leucine rich repeat protein phosphatase 1 antikoerper, PHLPP1 antikoerper, phlpp1 antikoerper, Phlpp1 antikoerper
    Hintergrund

    Description: Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family, specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity).

    Gene: PHLPP1

    Molekulargewicht
    184 kDa
    Gen-ID
    23239
    UniProt
    O60346
    Pathways
    PI3K-Akt Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung
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