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SH2B1 Antikörper (Internal Region)

SH2B1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6265047
  • Target Alle SH2B1 Antikörper anzeigen
    SH2B1 (SH2B Adaptor Protein 1 (SH2B1))
    Bindungsspezifität
    • 9
    • 8
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Internal Region
    Reaktivität
    • 39
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 33
    • 3
    • 2
    • 2
    Kaninchen
    Klonalität
    • 39
    • 1
    Polyklonal
    Konjugat
    • 23
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SH2B1 Antikörper ist unkonjugiert
    Applikation
    • 30
    • 16
    • 8
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Spezifität
    SH2B1 Antibody detects endogenous levels of total SH2B1.
    Homologie
    Horse,Sheep,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human SH2B1, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product SH2B1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    SH2B1 (SH2B Adaptor Protein 1 (SH2B1))
    Andere Bezeichnung
    SH2B1 (SH2B1 Produkte)
    Synonyme
    zgc:158474 antikoerper, SH2B3 antikoerper, PSM antikoerper, SH2B antikoerper, AI425885 antikoerper, C530001K22Rik antikoerper, Irip antikoerper, SH2-B antikoerper, SH2-Bb antikoerper, Sh2bpsm1 antikoerper, mKIAA1299 antikoerper, Sh2-b antikoerper, Sh2b antikoerper, SH2B adaptor protein 1 antikoerper, SH2B1 antikoerper, sh2b1 antikoerper, Sh2b1 antikoerper
    Hintergrund

    Description: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway, prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis (By similarity).

    Gene: SH2B1

    Molekulargewicht
    79kDa
    Gen-ID
    25970
    UniProt
    Q9NRF2
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