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SIRT3 Antikörper (C-Term)

Name: SIRT3 Antikörper (C-Term)
SKU: ABIN6265092
Price: 698.46 EUR
Availability: InStock

SIRT3 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, ICC, IF Wirt: Kaninchen Polyclonal unconjugated

Western blot analysis of SIRT3 expression in Mouse Heart lysate,The lane on the left is treated with the antigen-specific peptide. (SIRT3 Antikörper (C-Term))

IF/ICC

ABIN6268681 at 1/100 staining Mouse testis tissue by IHC-P. (SIRT3 Antikörper (C-Term))

IHC

3 Abbildungen

(1 reference)

Produktnummer ABIN6265092

Datenblatt (PDF)

Target Alle SIRT3 Antikörper anzeigen

SIRT3 (Sirtuin 3 (SIRT3))
Bindungsspezifität
16

10

8

7

7

7

6

6

4

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
Reaktivität
93

40

17

9

5

4

4

4

3

3

2

2

2
Human, Maus, Ratte
Wirt
82

16

2

2

2
Kaninchen
Passende Sekundärantikörper
Klonalität
90

15
Polyklonal
Konjugat
56

15

12

6

5

5

1

1

1

1

1

1
Dieser SIRT3 Antikörper ist unkonjugiert
Applikation
91

61

40

10

8

6

5

5

5

2

2

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität

SIRT3 Antibody detects endogenous levels of total SIRT3.

Homologie

Sheep,Rabbit

Aufreinigung

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen

A synthesized peptide derived from human SIRT3, corresponding to a region within C-terminal amino acids.

Isotyp

IgG

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anti-Sirtuin 3 (SIRT3) (AA 5-257) antibody
SIRT3 Reaktivität: Maus WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 mg/mL

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

-20 °C

Informationen zur Lagerung

Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit

12 months
Li, Chen, Yang, He, He, Xia, Zhang, Xiang: "Single-walled carbon nanohorn aggregates promotes mitochondrial dysfunction-induced apoptosis in hepatoblastoma cells by targeting SIRT3." in: International journal of oncology, Vol. 53, Issue 3, pp. 1129-1137, (2018) (PubMed).
Target

SIRT3 (Sirtuin 3 (SIRT3))

Andere Bezeichnung

SIRT3 (SIRT3 Produkte)

Synonyme

zgc:158774 antikoerper, sirtuin antikoerper, SIR2L3 antikoerper, 2310003L23Rik antikoerper, AI848213 antikoerper, Sir2l3 antikoerper, sirtuin 3 antikoerper, sirt3 antikoerper, SIRT3 antikoerper, Sirt3 antikoerper

Hintergrund

Description: NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301).
Gene: SIRT3

Molekulargewicht

29 kDa

Gen-ID

23410

UniProt

Q9NTG7