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SMAD7 Antikörper (N-Term)

SMAD7 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6265178
  • Target Alle SMAD7 Antikörper anzeigen
    SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))
    Bindungsspezifität
    • 16
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 45
    • 27
    • 25
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 38
    • 7
    Kaninchen
    Klonalität
    • 39
    • 6
    Polyklonal
    Konjugat
    • 22
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SMAD7 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 15
    • 14
    • 14
    • 8
    • 7
    • 4
    • 4
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Spezifität
    Smad7 Antibody detects endogenous levels of total Smad7.
    Homologie
    Pig,Bovine,Rabbit,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human Smad7, corresponding to a region within N-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product SMAD7 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))
    Andere Bezeichnung
    SMAD7 (SMAD7 Produkte)
    Synonyme
    CRCS3 antikoerper, MADH7 antikoerper, MADH8 antikoerper, Smad7a antikoerper, Madh7 antikoerper, Smad10 antikoerper, madh7 antikoerper, xsmad7 antikoerper, wu:fj60c10 antikoerper, SMAD family member 7 antikoerper, SMAD family member 7 L homeolog antikoerper, SMAD7 antikoerper, Smad7 antikoerper, smad7.L antikoerper, smad7 antikoerper
    Hintergrund

    Description: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

    Gene: SMAD7

    Molekulargewicht
    46 kDa
    Gen-ID
    4092
    UniProt
    O15105
    Pathways
    Interferon-gamma Pathway, Cell-Cell Junction Organization
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