SUPT4H Antikörper (C-Term)

Produktnummer ABIN6265266

Produktdetails anti-SUPT4H Antikörper

Target: SUPT4H (SUPT4H1) (Suppressor of Ty 4 Homolog 1 (SUPT4H1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUPT4H Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: SPT4H Antibody detects endogenous levels of total SPT4H.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human SPT4H, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu SUPT4H

Target: SUPT4H (SUPT4H1) (Suppressor of Ty 4 Homolog 1 (SUPT4H1))

Andere Bezeichnung: SUPT4H1 (SUPT4H1 Produkte)

Synonyme: SPT4 antikoerper, SPT4H antikoerper, SUPT4H antikoerper, Supt4h2 antikoerper, AL022777 antikoerper, Supt4h antikoerper, Supt4h1 antikoerper, Supt4h1a antikoerper, 142904_at antikoerper, CG12372 antikoerper, DSIF antikoerper, Dmel\\CG12372 antikoerper, Dspt4 antikoerper, Spt4 antikoerper, dDSIF antikoerper, dspt4 antikoerper, l(2)k05316 antikoerper, DSIF small subunit antikoerper, spt4 antikoerper, zgc:92824 antikoerper, SPT4 homolog, DSIF elongation factor subunit antikoerper, suppressor of Ty 4A antikoerper, Transcription elongation factor SPT4 antikoerper, CG12372 gene product from transcript CG12372-RA antikoerper, SPT4 homolog, DSIF elongation factor subunit L homeolog antikoerper, transcription elongation factor antikoerper, transcription elongation factor complex subunit Spt4 antikoerper, SUPT4H1 antikoerper, Supt4h1 antikoerper, Supt4a antikoerper, spt-4 antikoerper, spt4 antikoerper, supt4h1.L antikoerper, CAALFM_C504630WA antikoerper, supt4h1 antikoerper

Hintergrund:

Description: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

Gene: SUPT4H1

Molekulargewicht: 13 kDa

Gen-ID: 6827

UniProt: P63272