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SUV39H1 Antikörper (C-Term)

SUV39H1 Reaktivität: Human, Maus WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6265384
  • Target Alle SUV39H1 Antikörper anzeigen
    SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))
    Bindungsspezifität
    • 18
    • 15
    • 7
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 67
    • 17
    • 7
    • 5
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Maus
    Wirt
    • 59
    • 8
    Kaninchen
    Klonalität
    • 59
    • 8
    Polyklonal
    Konjugat
    • 23
    • 7
    • 6
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SUV39H1 Antikörper ist unkonjugiert
    Applikation
    • 39
    • 34
    • 13
    • 13
    • 11
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Spezifität
    SUV39H1 Antibody detects endogenous levels of total SUV39H1.
    Homologie
    Pig,Bovine,Rabbit,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human SUV39H1, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product SUV39H1 Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))
    Andere Bezeichnung
    SUV39H1 (SUV39H1 Produkte)
    Synonyme
    H3-K9-HMTase 1 antikoerper, KMT1A antikoerper, MG44 antikoerper, SUV39H antikoerper, AI852103 antikoerper, AL022883 antikoerper, DXHXS7466e antikoerper, mIS6 antikoerper, RGD1565028 antikoerper, kmt1a antikoerper, suv39h antikoerper, fe02c04 antikoerper, suv39h1 antikoerper, wu:fe02c04 antikoerper, zgc:101027 antikoerper, fe47h06 antikoerper, wu:fb18a10 antikoerper, wu:fe47h06 antikoerper, zgc:136593 antikoerper, suppressor of variegation 3-9 homolog 1 antikoerper, suppressor of variegation 3-9 homolog 1 (Drosophila) antikoerper, suppressor of variegation 3-9 homolog 1 L homeolog antikoerper, suppressor of variegation 3-9 homolog 1a antikoerper, suppressor of variegation 3-9 homolog 1b antikoerper, SUV39H1 antikoerper, Suv39h1 antikoerper, suv39h1.L antikoerper, suv39h1a antikoerper, suv39h1b antikoerper
    Hintergrund

    Description: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

    Gene: SUV39H1

    Molekulargewicht
    47 kDa
    Gen-ID
    6839
    UniProt
    O43463
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