TAP2 Antikörper (Internal Region)
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- Target Alle TAP2 Antikörper anzeigen
- TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))
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Bindungsspezifität
- Internal Region
- Reaktivität
- Human, Ratte, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TAP2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Spezifität
- TAP2 Antibody detects endogenous levels of total TAP2.
- Homologie
- Pig,Horse,Rabbit,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human TAP2, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product TAP2 Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))
- Andere Bezeichnung
- TAP2 (TAP2 Produkte)
- Synonyme
- ABC18 antikoerper, ABCB3 antikoerper, APT2 antikoerper, D6S217E antikoerper, PSF-2 antikoerper, PSF2 antikoerper, RING11 antikoerper, AI462429 antikoerper, Abcb3 antikoerper, Ham-2 antikoerper, Ham2 antikoerper, MTP2 antikoerper, Tap-2 antikoerper, Y1 antikoerper, jas antikoerper, Cim antikoerper, transporter 2, ATP binding cassette subfamily B member antikoerper, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) antikoerper, TAP2 antikoerper, Tap2 antikoerper
- Hintergrund
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Description: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Gene: TAP2
- Molekulargewicht
- 76kDa
- Gen-ID
- 6891
- UniProt
- Q03519
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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